Lumenal Transmission of Decapentaplegic in Drosophila Imaginal Discs
نویسندگان
چکیده
منابع مشابه
Lumenal transmission of decapentaplegic in Drosophila imaginal discs.
Drosophila imaginal discs are sac-like appendage primordia comprising apposed peripodial and columnar cell layers. Cell survival in disc columnar epithelia requires the secreted signal Decapentaplegic (DPP), which also acts as a gradient morphogen during pattern formation. The distribution mechanism by which secreted DPP mediates global cell survival and graded patterning is poorly understood. ...
متن کاملcAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs
Localized expression of decapentaplegic (dpp) is required for proper development of the Drosophila imaginal discs. Using genetic mosaics, we show that in the anterior compartment of appendage discs and anterior to the morphogenetic furrow in the eye disc, cells that lack cAMP-dependent protein kinase (PKA) activity ectopically express dpp. Pka- cells can influence the fate of neighboring cells ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2002
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(02)00264-2